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STAT3 Protein & Immune Cells Role in Psoriasis
1.
STAT 3
Protein & Immuno Competent Cells Cross Talks in Psoriasis M.YOUSRY ABDEL-MAWLA,MD Zagazig Faculty of Medicine,Egypt.
2.
3.
Cytokines and growth
factors that activate STAT proteins
4.
5.
6.
7.
8.
9.
Regulation of the
STAT3 signal transduction pathway
10.
Regulation of intracellular
Stat3 signalling .
11.
12.
13.
Effects of STAT3
Deficiency on Cellular Function Stuart et al.T he Journal of Immunology, 2009, 182: 21–28
14.
15.
Psoriasis
16.
17.
Psoriasis Clinical Presentation
18.
Clinical Manifestations
of Psoriasis
19.
20.
21.
22.
23.
24.
25.
26.
Immunopathology of Psoriasis
( ( Nickoloff & Nestle : J Clin Invest 2004; 113: 1664–1675.).
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
Keratinocytes cross
talks among immune cells in psoriasis
37.
38.
39.
40.
41.
42.
43.
Serum IL17
& IL22 in psoriasis Inas Almakhzangy & A. Gaballa Egyptian Dermatology Online Journal 5 (1): 4, 2009
44.
45.
46.
47.
48.
49.
50.
Keratinocytes cross
talks with immune cells in psoriasis
51.
52.
53.
Proinflammatory Effects
of IL17
54.
Roles of
IL-23 on T Helper 17 cells in Chronic Inflammation in Psoriasis Adapted from Iwakura & Ishigame, J Clin Invest 116:1218-1222 (2006) Dendritic cell Macrophage IL-23 IL-12 Th1 Th17 IFN IL-1, IL-6 TNF Inflammatory response Endothelial cells Stromal cells Epithelial cells Fibroblasts Macrophage IL-17, IL-6 IL-1 IL-6 IL-8 TNF IL-12R IL-23R IL-23R
55.
56.
57.
Toll like Receptor
(TLR) in Th17 -mediated Autoimmune Inflammation ( Goriely S, Neurath M, Goldman M, Nature Rev Immunol 2007 ) IL-23 IL-12 IL-27 TLR3 TLR2 Th1 Th1 Th17 IFN- Autoimmune Inflammation polyI : C PGN IFN-
58.
59.
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
A Tender
Piece of Information
70.
71.
Studies on Stat
3 in Psoriasis
72.
Stat 3 in
Psoriasis
73.
74.
75.
76.
Manipulation of Psorasis
77.
78.
Therapeutic Targets in
Psoriasis As a T Helper 17 Cell-Mediated Disease
79.
Anti TNF approved
for psoriasis treatment JEADV 2010, 24 (Suppl. 5), 2–24
80.
81.
82.
83.
84.
85.
86.
Current Rheumatology Reports
2007 , 9:461–467
87.
88.
89.
Future Psoriasis
Therapy ( Wippel-Slupetzky&Stingl Curr Probl Dermatol., 2009, 38, : 172–189 )
90.
Future Psoriasis
Therapy ( Wippel-Slupetzky&Stingl Curr Probl Dermatol., 2009, 38, : 172–189 )
91.
92.
93.
94.
95.
THANK YOU
Editor's Notes
39
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